2. Ερευνητικές δημοσιεύσεις | Research publications

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https://hdl.handle.net/10889/2147
Η συλλογή αυτή συγκεντρώνει τις δημοσιεύσεις του διδακτικού και ερευνητικού προσωπικού του Πανεπιστημίου Πατρών σε επιστημονικά περιοδικά ή σε επιστημονικές εκδηλώσεις (συνέδρια, ημερίδες, κλπ.).

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Browsing 2. Ερευνητικές δημοσιεύσεις | Research publications by Author "Antimisiaris, Sophia"

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    Mutant KRAS promotes malignant pleural effusion formation
    Agalioti, Theodora; Giannou, Anastasios; Krontira, Anthi; Kanellakis, Nikolaos; Kati, Danai; Vreka, Malamati; Pepe, Mario; Spella, Magda; Lilis, Ioannis; Zazara, Dimitra; Nikolouli, Eirini; Spiropoulou, Nikolitsa; Papadakis, Andreas; Papadia, Konstantina; Voulgaridis, Apostolos; Stamou, Panagiota; Meiners, Silke; Eickelberg, Oliver; Snyder, Linda; Antimisiaris, Sophia; Kardamakis, Dimitrios; Psallidas, Ioannis; Marazioti, Antonia; Stathopoulos, Georgios; Αγαλιώτη, Θεοδώρα; Γιάννου, Αναστάσιος; Κροντηρά, Ανθή; Κανελλάκης, Νικόλαος; Κατή, Δανάη; Βρεκά, Μαλαματή; Σπέλλα, Μάγδα; Λιλής, Ιωάννης; Ζαζάρα, Δήμητρα; Νικολούλη, Ειρήνη; Σπυροπούλου, Νικολίτσα; Παπαδάκης, Ανδρέας; Παπαδιά, Κωνσταντίνα; Βουλγαρίδης, Απόστολος; Χαροκόπος, Βαγγέλης; Στάμου, Παναγιώτα; Αντιμησιάρη, Σοφία; Καρδαμάκης, Δημήτριος; Ψαλλίδας, Ιωάννης; Μαραζιώτη, Αντωνία; Σταθόπουλος, Γεώργιος
    Τμήμα Ιατρικής (Δημοσ. Π.Π. σε περιοδικά)
    Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However, the mechanisms responsible for the development of MPE are still obscure. Here we show that mutant KRAS is important for MPE induction in mice. Pleural disseminated, mutant KRAS bearing tumour cells upregulate and systemically release chemokine ligand 2 (CCL2) into the bloodstream to mobilize myeloid cells from the host bone marrow to the pleural space via the spleen. These cells promote MPE formation, as indicated by splenectomy and splenocyte restoration experiments. In addition, KRAS mutations are frequently detected in human MPE and cell lines isolated thereof, but are often lost during automated analyses, as indicated by manual versus automated examination of Sanger sequencing traces. Finally, the novel KRAS inhibitor deltarasin and a monoclonal antibody directed against CCL2 are equally effective against an experimental mouse model of MPE, a result that holds promise for future efficient therapies against the human condition.