Δημοσιεύσεις σε συνέδρια

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Browsing Δημοσιεύσεις σε συνέδρια by Subject "Atorvastatin Calcium"

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    Open Access
    Identification of drug polymorphs in tablets
    (2012-05-04) Kontoyannis, Christos; Orkoula, Malvina; Karampas, Ioannis; Zissi, Georgia; Skorda, Dimitra; Serpi, E; Κοντογιάννης, Χρήστος; Όρκουλα, Μαλβίνα; Καραμπάς, Ιωάννης; Ζήση, Γεωργία; Σκορδά, Δήμητρα; Σέρπη, Ελευθερία
    Τμήμα Φαρμακευτικής (Δημοσ. Π.Π. σε συνέδρια)
    Polymorphs of an Active Pharmaceutical Ingredient (API) can have different chemical and physical properties and, thus, a direct impact on the process-ability of the drug substance and the quality/performance of the drug product, such as stability, dissolution, and bioavailability. Therefore, identification of the crystal phase of an API is of outmost importance. In this work methodologies were developed based on X-ray powder diffraction and IR for the identification of the crystal phase of two APIs (Atorvastatin Calcium and Donepezil HCl) in commercial tablets.