In silico study of blood flow as biomechanical determinant of plaque formation and localization

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Ζωγόγιαννη, Φρειδερίκη
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Our study was designed to test the hypothesis that flowfield properties such as WSS are closely related to cardiovascular disease. The spatial distribution patterns of several hemodynamic indices (gradient of WSS) were examined and compared with the (known) locations of plaque formation in human aorta. The part of the aorta on which we focused is ascending, aortic arch and descending aorta. Blood flow is influenced by vessel wall motion. Fluid Structure Interaction (FSI) is also investigated and discussed during the description of hemodynamic environment that leads to plaque formation in human aorta. Our Data were DICOM files from Computed Tomography (CT) scans. Using Vascular Modeling Toolkit (VMTK) and these scans as the input, we choose level set segmentation method to extract the geometry of the vessel needed for the simulation. ANSYS CFX Solver was used for the simulation of blood flow. The present numerical study revealed a direct correlation between low WSS values and atherosclerotic plaque localization. The results indicate also that Oscillating Shear Index (OSI) shows clearly points where the possibility of atherogenesis is high enough to be ignored. FSI provides unimportant details when we focused on plaque formation.
Wall shear stresses, Simulation