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Title: Identification of drug polymorphs in tablets
Authors: Kontoyannis, Christos
Orkoula, Malvina
Karampas, Ioannis
Zissi, Georgia
Skorda, Dimitra
Serpi, E
Issue Date: 2012-05-04
Keywords: Polymorphs
Active Pharmaceutical Ingredient (API)
Donepezil HCl
Atorvastatin Calcium
X-ray powder diffraction
Crystal phase
Keywords (translated): Πολύμορφα
Δραστική φαρμακευτική ουσία
Υδροχλωρική Δονεπεζίλη
Περίθλαση ακτίνων Χ
Φασματοσκοπία υπερύθρου
Κρυσταλλική φάση
Event: Πανελλήνιο Φαρμακευτικό Συνέδριο, 13ο
Abstract: Polymorphs of an Active Pharmaceutical Ingredient (API) can have different chemical and physical properties and, thus, a direct impact on the process-ability of the drug substance and the quality/performance of the drug product, such as stability, dissolution, and bioavailability. Therefore, identification of the crystal phase of an API is of outmost importance. In this work methodologies were developed based on X-ray powder diffraction and IR for the identification of the crystal phase of two APIs (Atorvastatin Calcium and Donepezil HCl) in commercial tablets.
Appears in Collections:Τμήμα Φαρμακευτικής (Δημοσ. Π.Π. σε συνέδρια)

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