Development of osmotic disrupting lipid nanocapsules for intravenously administrable cancer therapy
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Date
2024-06-18
Authors
Hasnat, Nur E
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Abstract
This research emphasizes the complexity of cancer, an enormous worldwide health concern. The creation of osmotic disrupting lipid nanocapsules (LNCs) as a novel method for intravenous cancer therapy is the main emphasis of this study. In order to improve treatment efficacy, the study looks into encasing sodium chloride (NaCl) nanocrystals into LNCs and disrupting the osmotic pressure in cancer cells. To assure stability and control over the nanocrystal size, NaCl nanocrystals were effectively produced using the antisolvent crystallization method and coated with oleic acid and oleylamine.
The oil core for the LNCs was ethyl oleate, and the formulation process used the phase-inversion temperature (PIT) method. Significant variations in the coating agent efficacy of oleic acid and oleylamine were observed in experimental comparisons, both in isolation and in combination.
This work offers a novel therapeutic approach that can target cancer cells by utilizing osmotic disruption and nanotechnology. According to the results, the created LNCs may present a feasible avenue for the advancement of cancer therapy, possibly leading to better patient outcomes and laying the groundwork for future studies on nanomedicine-based cancer therapies.
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Keywords
Lipid nanocapsules (LNC), Sodium chloride nanocrystals, Osmotic pressure, Cancer therapy, Phase-inversion temperature, Oleic acid, Oleylamine